Professional information

Publications:

2008:

Conant, G. C., and K. H. Wolfe. (2008) GenomeVx: Simple web-based creation of editable circular chromosome maps, Bioinformatics 24: 861-862. [Reprint] .

Powell, A. J., G. C. Conant, D. E. Brown, I. Carbone and R. A. Dean. (2008) Altered patterns of gene duplication and differential gene gain and loss in fungal pathogens, BMC Genomics 9: 147. [Reprint]

Conant, G. C. and K. H. Wolfe. (2008) Probabilistic cross-species inference of orthologous genomic regions created by whole-genome duplication in yeast, Genetics 179: 1681-1692. [Reprint]

2007:

Conant, G. C., G. P. Wagner and P. F. Stadler. (2007) Modeling amino acid substitution patterns in orthologous and paralogous genes, Molecular Phylogenetics and Evolution, 42: 298-307. [Email for reprint]

Scannell, D. R., A. C. Frank, G. C. Conant, K. P. Byrne, M. Woolfit and K. H. Wolfe. (2007) Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication, Proceedings of the National Academy of Sciences, U.S.A., 104: 8397-8402. [Reprint]

Conant, G. C., and K. H. Wolfe. (2007) Increased glycolytic flux as an outcome of whole-genome duplication in yeast, Molecular Systems Biology, 3: 129. [Reprint]

2006:

Conant, G. C., and K. H. Wolfe. (2006) Functional partitioning of yeast co-expression networks after genome duplication, PLoS Biology,4: e109. [Reprint]

2005:

Conant, G. C., and A. Wagner. (2005) The rarity of gene shuffling in conserved genes, Genome Biology, 6: R50 [Reprint]

2004:

Conant, G. C. and A. Wagner. (2004) Duplicate genes and robustness to transient gene knockouts in Caenorhabditis elegans, Proceedings of the Royal Society, Biological Sciences, 271: 89-96 [Reprint]

Hahn, M. H., G. C. Conant and A. Wagner. (2004) Molecular evolution in large genetic networks: Does connectivity equal constraint? Journal of Molecular Evolution, 58: 203-211. [Reprint][Original Article available at www.springerlink.com] Copyright retained by Springer-Verlag, NY.

Conant, G. C., and A. Wagner. (2004) A fast algorithm for determining the best combination of local alignments to a query sequence, BMC Bioinformatics, 5: 62 [Reprint]

Babu, S. R., G. C. Conant, E. Eller, C. M. Roberts, K. Gowan, G. S. Eisenbarth, P. R. Fain, and P. Vardi. (2004) A Second-generation genome screen for linkage to Type 1 diabetes in a Bedouin Arab family, Annals of the New York Academy of Sciences,1037: 157-160

2003:

Conant, G. C. and A. Wagner. (2003) Convergent evolution of gene circuits, Nature Genetics, 34: 264-266 [Reprint][Supplemental Methods][Nature Genetics Online]

Conant, G. C., S. J. Plimpton, W. Old, A.Wagner, P. R. Fain, T. R. Pacheco and G. Heffelfinger. (2003) Parallel Genehunter: Implementation of a linkage analysis package for distributed-memory architectures, Journal of Parallel and Distributed Computing, 63: 674-682.[Corrected Pre-Print][Email for reprint]

Conant, G. C. and A. Wagner. (2003) Asymmetric sequence divergence of duplicate genes, Genome Research, 13: 2052-2058. [Reprint]

2002:

Conant, G. C. and A. Wagner. (2002) GenomeHistory: A software tool and its application to fully sequenced genomes, Nucleic Acids Research, 30: 3378-3386 [Reprint]

2001:

Conant, G. C. and P. O. Lewis. (2001) Effects of nucleotide composition bias on the success of the parsimony criterion in phylogenetic inference, Molecular Biology and Evolution, 18: 1024-1033 [Reprint]

Conference Papers and Presentations:

Parallel Genehunter: Implementation of a Linkage Analysis Package for Distributed-Memory Architectures, First IEEE Workshop on High Performance Computational Biology, at the International Parallel and Distributed Computing Symposium, Ft. Lauderdale, FL, April 2002 [Paper Reprint: old version of JDPC paper]

Dissertation

Software Packages:

Package Name	Collaborators	Reference	Function
GenomeHistory	Andreas Wagner	Nucleic Acids Research, 2002	Duplicate gene identification
Parallel Genehunter	Steve Plimpton	Journal of Parallel and Distributed Computing, 2003	Parallel Genetic linkage analysis
Find_max_cover	Andreas Wagner	BMC Bioinformatics, 2004	Combination of sequence alignments
GenomeVx	Ken Wolfe	Bioinformatics, 2008	Circular chromosome visualization

Biographical Information

Education:

Dates	Institution/Department	Degree
1998-2004	Department of Biology, The University of New Mexico	Ph. D., Biology
1995-1998	The University of New Mexico	B.S., Biology
1994-1995	University of Puget Sound

Employment

Institution	Position	Supervisor	Dates
University of Missouri	Assistant Professor		September 2008-present
Trinity College	Post-doctoral Fellow	Prof. Kenneth Wolfe	2005-2008
University of Leipzig	Post-doctoral Fellow	Prof. Peter Stadler	2004

Funding/Fellowships:

Funding Source:	Dates
Computational Sciences Graduate Fellowship (Department of Energy)	2000-2004
Albuquerque High Performance Computing Center	1998-2004

Research Interests:

Evolution of duplicate genes in genomes

Using probabilistic models of biological sequence evolution to infer functional information.

Molecular phylogenetics, especially phylogenetic inference via maximum likelihood.

I spent a summer at Sandia National Laboratories' Computational Sciences Research Institute, working on creating a massively parallel version of the program Genehunter. Genehunter is used to locate genetic markers associated with inheritable diseases.

Posters:

Conant, G. C. and Wagner, A. "Variation of Relative Rates of Amino Acid Substitution in Functionally Different Protein Classes,"
Computational Sciences Graduate Fellowship Conference, Washington D.C., 2001 and Mathematics And Molecular Biology VII, Santa Fe, NM, 2002.

Conant, G., Plimpton, S., Old, W., Wagner, A., Fain, P., and Heffelfinger, G. "Parallel Genehunter: Implementation of a Linkage Analysis Package for Distributed-Memory Architectures," The Conference on High Speed Computing, Gleneden Beach, OR, 2002 and Computational Sciences Graduate Fellowship Conference, Washington D. C., 2002.

Teaching:

I have taught the Anatomy and Physiology I lab at UNM and given lectures in molecular evolution to Molecular Medicine masters degrees students at Trinity.